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Interim findings from the phase III trial are not expected to be available until March 2017; however, clinical interest in potential off-label use of obeticholic acid is likely to be great, given the lack of available treatments with liver-specific effects.

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Moreover, data from another recent clinical trial have also revealed that orally active MS-209 plus cyclophosphamide, doxorubicin, and fluorouracil (CAF) therapy was well tolerated and improved the progression-free survival in patients with advanced or recurrent breast cancer who had not received previous therapy in comparison with CAF treatment alone.

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