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This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism).

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Rockville, MD: Agency for Healthcare Research and Quality; 2010.

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Adverse effects include insomnia, migraines, depression, hot flashes, diarrhea, anorexia, cramps, vaginitis, urinary tract infection, leukorrhea, endometrial disorder, breast pain, rash, sweating, weight gain, peripheral edema, arthralgia, myalgia, leg cramps, arthritis, sinusitis, pharyngitis, increased cough, pneumonia, and laryngitis.

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Medicare and Medicaid cohorts, patients initiating raloxifene were also less likely to have had a fracture or a BMD screen in the pre-period than patients initiating bisphosphonate therapy.

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Synapses in the arcuate nucleus and in the CA1 region of the hippocampus exhibit a phasic remodeling, coordinated with fluctuation in hormone levels during the estrous cycle ().

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Pharmacologic therapy was initiated in 89% of these patients, with 69 patients receiving calcium and vitamin D, and 20 patients receiving bisphosphonates.

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